منابع مشابه
A Hybrid Recombinant-Chemical Conjugation Approach to Fc Fusion Mimetics
H. Khalili, S. Brocchini, P. Khaw University College London Purpose We have recently shown that Fab-PEG-Fab (FpF) molecules are antibody (MAb) mimetics [1]. Site-specific conjugation of the Fab in the region where it is naturally bound to the hinge in a MAb to each terminus of a linear PEG molecule yields the FpF. Since the PEG in FpFs appears to allow good avidity of the Fabs, and better stabi...
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This new, comprehensive text published by Wiley Blackwell provides a much needed re-write on the earlier publication of 15 y ago, published just after the approval of the first Fc-fusion protein, etanercept (Enbrel). The field of therapeutic proteins, dominated by antibodies and Fc-fusion proteins, has advanced dramatically over this period, with multiple new structures and successful therapeut...
متن کاملOral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.
BACKGROUND The alpha and beta subunits of FSH were fused to the Fc domain of IgG1 either in a single chain or a heterodimer format. These molecules were absorbed through the epithelium in lung and intestine by neonatal Fc receptor (FcRn)-mediated transcytosis. METHODS AND RESULTS Single chain and heterodimer FSH-Fc were made recombinantly in Chinese hamster ovary cells. Treatment of rats with...
متن کاملExpression and characterization of a DNase I-Fc fusion enzyme.
Recombinant human deoxyribonuclease I (DNase I) is an important clinical agent that is inhaled into the airways where it degrades DNA to lower molecular weight fragments, thus reducing the viscoelasticity of sputum and improving the lung function of cystic fibrosis patients. To investigate DNases with potentially improved properties, we constructed a molecular fusion of human DNase I with the h...
متن کاملFc-fusion proteins: new developments and future perspectives
Since the first description in 1989 of CD4-Fc-fusion antagonists that inhibit human immune deficiency virus entry into T cells, Fc-fusion proteins have been intensely investigated for their effectiveness to curb a range of pathologies, with several notable recent successes coming to market. These promising outcomes have stimulated the development of novel approaches to improve their efficacy an...
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ژورنال
عنوان ژورنال: Biomaterials Science
سال: 2016
ISSN: 2047-4830,2047-4849
DOI: 10.1039/c6bm00077k